Publications

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  1. Karla N. Valenzuela-Valderas, Elmira Farrashzadeh, Yuen-Yan Chang, Yunnuo Shi, Renee Raudonis, Brendan M. Leun, John R. Rohd, Jost Enninga, Zhenyu Cheng “RACK1 promotes Shigella flexneri actin-mediated invasion, motility and cell-to-cell spreading” (2023) iScience (doi: https://doi.org/10.1016/j.isci.2023.108216)
  2. Morgan Pugh-Toole, Nicholas Dawe, Jeanette E. Boudreau, Brendan M. Leung “Tumor Spheroids Layered in an Imageable Cancer Environment (T-SLICE): a novel in vitro platform to study tumor biology” (2022) bioRxiv (doi: https://doi.org/10.1101/2022.10.08.511443)

2023

  1. Courtney L. O’Brien, Sarah Spencer, Naeimeh Jafari, Andy J. Huang, Alison J. Scott, Zhenyu Cheng, Brendan M. Leung “Modeling Cystic Fibrosis Chronic Infection Using Engineered Mucus-like Hydrogel” (2023) ACS Biomaterials Science & Engineering (doi:10.1021/acsbiomaterials.4c01271)

2022

  1. Gavin Raddall, Isabel Mello, Brendan M Leung “Effects of intracanal antimicrobials on viability and differentiation of stem cells from the apical papilla in vitro” (2022) Journal of Endodontics (DOI: 1016/j.joen.2022.04.003)
  2. Andy Huang, Courtney L. O’Brien, Nicholas Dawe, Anas Tahir, Alison J. Scott, Brendan M. Leung, “Characterization of an Engineered Mucus Microenvironment for In Vitro Modeling of Host-Microbe Interaction” Scientific Reports (2022) 12, Article number: 5515 (DOI:10.1038/s41598-022-09198-6)
  3. Morgan Pugh-Toole, Anna P Nicolela, Sarah Nersesian, Brendan M Leung, Jeanette E Boudreau, “Natural Killer Cells: the Missing Link in Effective Treatment for High-Grade Serous Ovarian Carcinoma”.  Treat. Options in Oncol.(2022). https://doi.org/10.1007/s11864-021-00929-x

2021

  1. Andy Huang, Andrew N Clarke, Naeimeh Jafari, Brendan Leung, “Characterization of patterned microbial growth dynamics in aqueous two-phase polymer scaffolds” ACS Biomaterials Sciences and Engineering (2021), Dec 13;7(12):5506-5514. doi: 10.1021/acsbiomaterials.1c01130

2019

  1. Gavin Raddall, Isabel Mello, Brendan Leung, “Biomaterials and scaffold design strategies for regenerative endodontic therapy” Front. Bioeng. Biotechnol., 15 November 2019, doi:10.3389/fbioe.2019.00317
  2. Oliver CR., Altemus MA., Westerhof TM., Cheriyan H., Cheng X., Dziubinski M., Wu Z., Yates J., Morikawa A., Heth J., Castro MG., Leung BM., Takayama S., Merajver SD., “A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche” Lab on a Chip, in press (2019) doi:10.1039/c8lc01387j

2018

  1. Teixeira A.G., Agarwal R., Ko K.R., Grant-Burt J, Leung B.M., Frampton J.P., “Emerging Biotechnology Applications of Aqueous Two-Phase Systems” Adv. Healthcare Mat. doi: 10.1002/adhm.201701036

2017

  1. Labuz J.M., Moraes, C., Mertz, D., Leung, B.M., Takayama, S. “Building an experimental model of the human body with non-physiological parameters.” Technology. 5: 42-59. doi: 10.1142/S2339547817500029
  2. Lesher-Perez S.C., Kim G.A., KuoC.H., Leung B.M., Mong S, Kojima T., Moraes C.M,  Thouless M.D., Luker G.D., Takayama S., “Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures.” Biomaterial Sciences.

2016

  1. Kim, S.J.; Lesher-Perez, S.C.; Kim, B.C.; Yamanashi, C.; Labuz, J.; Leung, B.M.; Takayama, S.; “Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip.” Biofabrication.  doi: 10.1088/1758-5090/8/1/015021.

Selected publications prior to 2016

  1. Frampton J.P., Leung B.M., Bingham E.L., Lesher-Perez S.C., Wang J.D., Sarhan H.T., El-Sayed M, Feinberg S.E., Takayama S.. (2015). “Rapid Self-Assembly of Macroscale Tissue Constructs at Biphasic Aqueous Interface.” Advanced Functional Materials. 25(11): 1694-1699
  2. Leung B.M.*, Moraes C*, Cavnar S.P., Luker K.E., Luker G.D. Takayama S., “Microscale 3D collagen cell culture assays in conventional flat-bottom 384-well plates” Journal of Laboratory Automation, DOI: 10.1177/2211068214563793 (2014)
  3. Leung, B.M.*, Lesher-Perez, S.C.*, Matsuoka, T., Moraes, C., Takayama, S., “Medium Additives to promote circularity and compactness in hanging drop spheroid culture.”, Biomaterial Sciences, DOI:10.1039/c4bm00319e, (2014)
  4. Dwidar M., Leung B.M., Yaguchi T., Takayama S., Mitchell R.J., “Patterning bacterial biofilm on epithelial cells”, PloS one 8, e67165, doi:10.1371/journal.pone.0067165 (2013)
  5. Leung B.M., Miyagi Y., Li R.K., Sefton M.V., “Fate of modular cardiac tissue constructs in a syngeneic rat model”, Journal of Tissue Engineering and Regenerative Medicine, doi:10.1002/term.1724 (2013)
  6. Yaguchi T., Dwidar M., Byun C.K., Leung B.M., Lee S., Chi Y.K., Mitchell R.J., Takayama S., “Aqueous two-phase system -derived biofilm for bacterial interaction studies”, Biomacromolecules 13, 2655-2661, doi:10.1021/bm300500y (2012)
  7. Leung B.M., Sefton M.V., “A modular approach to cardiac tissue engineering”, Tissue Engineering. Part A 16, 3207-3218, doi:10.1089/ten.TEA.2009.0746 (2010)